Establishment of immortalized periodontal ligament progenitor cell line and its behavioural analysis on smooth and rough titanium surface
, D. Padula 1,2,3, C. Popov 1, P. Weishaupt 4, M. Prägert 1, N. Miosge 5, R. Hickel 4, W. Böcker 1, H. Clausen-Schaumann 2,3, M. Schieker 11 Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig-Maximilians-University (LMU), Munich, Germany
2 Precision- and Micro-Engineering, Engineering Physics, Faculty 06, Munich University of Applied Sciences, Munich, Germany
3 Center for NanoScience, LMU, Munich, Germany
4 Department of Restorative Dentistry and Periodontology, Dental School of the LMU, Munich, Germany
5 Department of Prosthodontics, Georg-August-University of Göttingen, Göttingen, Germany
Abstract
Periodontal ligament (PDL) can be obtained from patients undergoing orthodontic treatment. PDL contains progenitor cells that can be expanded and differentiated towards several mesenchymal lineagesin vitro. Furthermore, PDL-derived cells have been shown to generate bone- and PDL-like structuresin vivo. Thus, PDL cells, combined with suitable biomaterials, represent a promising tool for periodontitis-related research and PDL engineering.
Keywords
- Scaffold
- titanium
- surface topography
- periodontal ligament
- progenitor cell
- biocompatibility
- osteogenic differentiation
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