Animal models of maternal nutrition and altered offspring bone structure – Bone development across the lifecourse
1 Bone and Joint Research Group, Human Development and Health, Institute of Developmental Sciences, University of Southampton School of Medicine, Southampton, SO16 6YD, U.K.
2 MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, SO16 6YD.
* These authors contributed equally as corresponding authors
Abstract
It is widely accepted that the likelihood of offspring developing heart disease, stroke, or diabetes in later life, is influenced by the theirin uteroenvironment and maternal nutrition. There is increasing epidemiological evidence that osteoporosis in the offspring may also be influenced by the mother’s nutrition during pregnancy. This review provides evidence from a range of animal models that supports the epidemiological data; suggesting that lifelong bone development and growth in offspring is determined during gestation.
Keywords
- Animal models
- bone
- bone development
- epidemiology
- epigenetics
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