A novel model ofin vitroosteocytogenesis induced by retinoic acid treatment
1 Renal Research Laboratory, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico & Fondazione D’Amico per la Ricerca sulle Malattie Renali, Milano, Italy
2 Department of Nephrology, Dialysis and Renal Transplant, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy
3 MIA Consortium for Image Analysis, La Bicocca University, Milan, Italy
4 Renal Physiopathology Laboratory, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
Abstract
Despite recent research which more and more stresses the importance of osteocytes in regulating bone and systemic mineral metabolism, current molecular and functional knowledge of osteocyte properties are still incomplete, mostly due to limited availability ofin vitromodels.
Keyword
- Retinoic acid; melatonin; osteoblast; osteocyte; sclerostin
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