IL-1β-pre-conditioned mesenchymal stem/stromal cells’ secretome modulates the inflammatory response and aggrecan deposition in intervertebral disc
J.R. Ferreira 1,2,3, G.Q. Teixeira 1,2,3,#, E. Neto 1,2, C. Ribeiro-Machado 1,2, A.M. Silva 1,2,3, J. Caldeira 1,2, C. Leite Pereira 1,2, S. Bidarra 1,2, A.F. Maia 1,4, M. Lamghari 1,2,3, M.A. Barbosa 1,2,3, R.M. Gonçalves 1,2,3,*
Affiliations
Article Info
1 I3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal
2 INEB – Instituto de Engenharia Biomédica, Universidade do Porto, Portugal
3 Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal
4 IBMC – Instituto Biologia Molecular e Celular, Universidade do Porto, Portugal
# Current address: Institute of Orthopaedic Research and Biomechanics, University of Ulm, Ulm, Germany
Graphical Abstract
Keywords
- Mesenchymal stem cells
- degenerative intervertebral discs
- immunomodulation
- secretome
- paracrine signalling
- extracellular matrix
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