Biocompatibility testing of differently structured titanium implants was performed using an in vitro test system of a newly established human fetal osteoblastic cell line (hFOB 1.19). Cell adhesion of osteoblastic cells on the different porous geometries and the suitability of a copper vapor laser system for surface structuring was tested with the following parameters: cell-number, cell viability, alkaline phosphatase expression.The analysis of the cell culture results demonstrated that 25�m and 200�m porous geometries showed similar or even better results than the negative control of polystyrene; there was no sign of toxic effects. However, the 100�m porous geometry showed an impressive negative influence on the calculated parameters. The reason for this effect is unclear.The series with 50�m, 300�m, 400�m and 500�m showed a comparable, intermediate effect on the cell culture with respect to the different parameters. However, the results were worse than with the 25 and 200�m porous geometry. In conclusion, the 25�m and 200�m porous geometry seems to have the most positive effect on the human osteoblastic cell line hFOB 1.19.